Lymphoma | Clinical Medicine

What's up, ninja nerds? In this video today, we're going to be talking about lymphoma. That includes non-hodkin and also Hchin lymphoma. Now, again, this is part of a clinical medicine section. If you guys like these videos, they make sense to you. Please support us. You can do that hitting the like button, pounding down the comment section, and subscribing. Also, down in the description box below, there's a link to our website. If you go there, you can access notes, illustrations, quiz questions by becoming a premium member. and I think it'll truly benefit you. Go check it out. All right, let's get into the pathophys. All right, my friends. So, we're going to talk about the pathophys. When we talk about lymphoma, it's an abnormality of lymphocytes. But if you guys go back to leukemia, leukemia was basically there was the acute and the acronics, but there was the lymphoid and the myoid kind of abnormalities. Those were problems where the abnormalities existed in the bone marrow and they just happened to get squirted out into the bloodstream and go and deposit into different organs. Right? In this scenario, you're not having that issue. the bone marrow is actually working properly and it's making proper lymphoblasts and prolymphocytes and naive lymphocytes right so when you think about hodkin lymphoma the abnormality really exists when you get into the lymph node so when we think about this let's say here we have our bone marrow and here is going to be our lymphoid stem cell and it goes through turns into a lymphoblast lymphoblast then differentiate into prolymphocytes and then eventually you get your lymphocytes and this will be your tlymph phosite here and this would be your belymphosy here. From that point the Tlymphosytes will then go where? Well, they go to the thymus because you know the thymus is where we take the naive tea cells. We undergo the selection process, positive, negative selection, everything else. And then from there we allow these to leave the thymus as primarily there's a couple other ones but primarily are they going to leave as a CD8 positive lymphocy or are they going to leave as a CD4 positive lymphocy and the importance of remembering that is that these will turn into your cytotoxic tea cells and these will turn into your helper tea cells and then you have other